A77 1726 (E/Z) Mixture

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Synonyms :2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide; 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide; rac-Teriflunomide; USP Leflunomide Related Compound B;

Description

rac A77 1726 is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a (Rebif®). Leflunomide USP Related Compound B.

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SKU	RCLST027177
CAS number	108605-62-5
Molecular Formula	C12H9F3N2O2
Catalog Number	RCLST027177
Chemical Name	A77 1726 (E/Z) Mixture
Synonyms	2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide; 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide; rac-Teriflunomide; USP Leflunomide Related Compound B;
Molecular Weight	270.21
Solubility	DMSO (Slightly), Methanol (Sparingly)
Stability	No Data Available
Appearance	White Solid
Storage Condition	Amber Vial, -20°C Freezer, Under inert atmosphere
Shipping Info	eh Dangerous Goods

A77 1726 (E/Z) Mixture

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