Skip to the beginning of the images gallery

Tacrolimus-13C,D2 (major)

Availability:In stock

FK-506-13C,D2 (Major) (Tacrolimus)

Unit

Quantity:

Note:

All Products are stable to be shipped at room temperature, unless otherwise specified.

Synonyms :Advagraf-13C,D2; FR 900506-13C,D2; Fujimycin-13C,D2; L 679934-13C,D2; Prograf-13C,D2; Protopic-13C,D2; TacroBell-13C,D2; Tacrolimus-13C,D2; Tsukubaenolide-13C,D2; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-

Description

A labeled immunosuppressant blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2.

Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.

More Information

More Information
SKU	RCLSTSS338
CAS number	1356841-89-8
Molecular Formula	C43(13C)H67D2N)12
Catalog Number	RCLESS338
Chemical Name	Tacrolimus-13C,D2 (major)
Synonyms	Advagraf-13C,D2; FR 900506-13C,D2; Fujimycin-13C,D2; L 679934-13C,D2; Prograf-13C,D2; Protopic-13C,D2; TacroBell-13C,D2; Tacrolimus-13C,D2; Tsukubaenolide-13C,D2; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-
Molecular Weight	807.02
Solubility	Chloroform (Slightly), Methanol (Slightly)
Appearance	White to Light Beige Solid
Storage Condition	Store at -20C in a dry place away from direct sunlight under nitrogen
Shipping Info	All Products are stable to be shipped at room temperature, unless otherwise specified. Dangerous good
Application Note	Compounds Can Strictly Be Provided For Research And Development Purposes. Compounds Are Not Intended For Animal/Human Testing And/Or Usage.

Products

Chemical Name : (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl-3-13C-2,2-d2)-15,

Synonyms : 9-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone;Advagraf-13C,D2; FR 900506-13C,D2; Fujimycin-13C,D2; L 679934-13C,D2; Prograf-13C,D2; Protopic-13C,D2; TacroBell-13C,D2; Tacrolimus-13C,D2; Tsukubaenolide-13C,D2

Smiles: CO[C@@H]1[C@]([C@H](C[C@H](C/C(C)=C\[C@@](C(C[C@H](O)[C@H]2C)=O)([H])C/C=[13C]([2H])/[2H])C)OC)([H])O[C@@](O)(C(C(N(CCCC3)[C@]3([H])C(O[C@@H]2/C(C)=C/[C@H](CC[C@H]4O)C[C@H]4OC)=O)=O)=O)[C@H](C)C1

Inchi: InChI=1S/C10H10ClN/c11-9-4-5-10-8(7-9)3-1-2-6-12-10/h1,3-5,7,12H,2,6H2

Alternate CAS # 104987-11-3 for unlabelled

References: Asano, K., et al.: In Vivo, 10, 537 (1996), McCall, E., et al.: Circ. Res., 79, 1110 (1996), Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996), Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., et al.: Brit. Med. J., 318, 1104 (1999),