Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and Patched.1 The KAAD-Cyclopamine has shown 10-20 fold higher potency than cyclopamine in inhibition of ß-Galactosidase expression in p2Ptch-1- cells, with similar or lower toxicity. KAAD-Cyclopamine compound is unstable in solution.
SKU | RCLST000171 |
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CAS number | 306387-90-6 |
Molecular Formula | C44H63N3O4 |
Catalog Number | RCLST000171 |
Chemical Name | 3-Keto-N-aminoethyl-N’-aminocaproyldihydrocinnamoyl Cyclopamine |
Synonyms | KAAD-Cyclopamine; |
Molecular Weight | 697.99 |
Solubility | Chloroform (Slightly), Methanol (Slightly) |
Stability | No Data Available |
Appearance | Off-White to Yellow Solid |
Storage Condition | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |