4-Amino-1-(tetrahydropyranyl)-1H-indazole

4-Amino-1-(tetrahydropyranyl)-1H-indazole is used as a reactant in the preparation of biheteroaryl arylamines as selective inhibitors of phosphoinositol 3-kinases (PI3K) and their selectivities for PI3K over mTOR and antitumor activities.