5-Fluoroorotic Acid Monohydrate (Ultra Pure)

In stock
Note:
All Products are stable to be shipped at room temperature, unless otherwise specified.
Synonyms :5-FOA

5-FOA has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in malarial parasites. The combination of 5-FOA and uracil has been effective in treating mice infected with Plasmodium yoelli. 5-FOA may also have potential in the treatment of human malarial infections when used in combination with other agents.

More Information
SKU RCLST000595
CAS number 220141-70-8
Molecular Formula C5H5FN2O5
Catalog Number RCLST000595
Chemical Name 5-Fluoroorotic Acid Monohydrate (Ultra Pure)
Synonyms 5-FOA
Boiling Pt No Data Available
Molecular Weight 192.1
Melting Pt >255°C (dec.)
Storage Condition -20°C Freezer
Stability No Data Available
Appearance Must be White Solid
Solubility Aqueous Base (Heated), DMSO (Sparingly, Heated), Methanol (Sparingly), Water (Slightly, Heated)
HS Commidity Code 2933.59.9500