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Aprepitant

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Synonyms :5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; Emend; L 754030; MK 0869; MK 869; ONO 7436;

Description

Aprepitant is a neurokinin-1 antagonist and an antiemetic agent (1). It is used to prevent chemotherapy-induced nausea and vomiting (CINV) in colorectal cancer patients (2) Aprepitant has also been shown to induce apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells (3).

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More Information
SKU	RCLST008927
CAS number	170729-80-3
Molecular Formula	C23H21F7N4O3
Catalog Number	RCLST008927
Chemical Name	Aprepitant
Synonyms	5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; Emend; L 754030; MK 0869; MK 869; ONO 7436;
Molecular Weight	534.43
Solubility	DMSO (Slightly), Methanol (Slightly)
Stability	No Data Available
Appearance	White to Pale Beige Solid
Storage Condition	-20°C Freezer

Aprepitant

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