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C646 is an inhibitor for histone acetyltransferase p300 and may be a potential candidate for treating AML1-ETO (AE) positive acute myeloid leukemia (AML). It is shown that C646 inhibited cellular proliferation, reduced colony formation, evoked partial cell cycle arrest in the G1 phase, and induced apoptosis in AE-positive AML cell lines and primary blasts isolated from leukemic mice and AML patients.
| SKU | RCLST599410 |
|---|---|
| CAS number | 328968-36-1 |
| Molecular Formula | C24H19N3O6 |
| Catalog Number | RCLST599410 |
| Chemical Name | C646 |
| Molecular Weight | 445.42 |
| Solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| Stability | No Data Available |
| Appearance | Dark Orange Solid |
| Storage Condition | Amber Vial, -20°C Freezer, Under inert atmosphere |
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