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Dorsomorphin Dihydrochloride

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All Products are stable to be shipped at room temperature, unless otherwise specified.
Synonyms :6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine Dihydrochloride; 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine Hydrochloride (1:2)

Dorsomorphin is an AMP-activated kinase (AMPK) inhibitor. Dorsomorphin selectively inhibits the bone morphogenetic protein (BMP) type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation. Dorsomorphin has shown to increase cisplatin-induced apoptosis, which was associated with hyper-induction of the tumor suppressor p53.

More Information
SKU RCLST019435
CAS number 1219168-18-9
Molecular Formula C24H27Cl2N5O
Catalog Number RCLST019435
Chemical Name Dorsomorphin Dihydrochloride
Synonyms 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine Dihydrochloride; 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine Hydrochloride (1:2)
Molecular Weight 472.41
Solubility DMSO (Slightly), Water (Slightly)
Stability No Data Available
Appearance Yellow Solid
Storage Condition Hygroscopic, Refrigerator, under inert atmosphere

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Dorsomorphin Dihydrochloride