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FK-506-13C,D2 (Major) (Tacrolimus) (>85%)

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Tacrolimus-13C, D2 (major)

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Synonyms :Advagraf-13C,D2; FR 900506-13C,D2; Fujimycin-13C,D2; L 679934-13C,D2; Prograf-13C,D2; Protopic-13C,D2; TacroBell-13C,D2; Tacrolimus-13C,D2; Tsukubaenolide-13C,D2; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-

Description

A labelled immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. A representative lot contained a distribution of 20% d-1, 40% d-2 and 20% d-3.

More Information

More Information
SKU	RCLSTF370002
CAS number	1356841-89-8
Molecular Formula	C4313CH67D2NO12
Catalog Number	RCLST200073
Chemical Name	FK-506-13C,D2 (Major) (Tacrolimus) (>85%)
Synonyms	Advagraf-13C,D2; FR 900506-13C,D2; Fujimycin-13C,D2; L 679934-13C,D2; Prograf-13C,D2; Protopic-13C,D2; TacroBell-13C,D2; Tacrolimus-13C,D2; Tsukubaenolide-13C,D2; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-
Molecular Weight	807.02
Solubility	Chloroform (Slightly), Methanol (Slightly)
Stability	No Data Available
Appearance	White to Off-White Solid
Storage Condition	-20°C Freezer, Under Inert Atmosphere
Shipping Info	eh Dangerous Goods
Application Note	Compounds Can Strictly Be Provided For Research And Development Purposes. Compounds Are Not Intended For Animal/Human Testing And/Or Usage.

Products

Chemical Name :(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl-3-13C-2,2-d2)-15,

Synonyms : 9-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone;Advagraf-13C,D2; FR 900506-13C,D2; Fujimycin-13C,D2; L 679934-13C,D2; Prograf-13C,D2; Protopic-13C,D2; TacroBell-13C,D2; Tacrolimus-13C,D2; Tsukubaenolide-13C,D2

Smiles: CO[C@@H]1[C@]([C@H](C[C@H](C/C(C)=C\[C@@](C(C[C@H](O)[C@H]2C)=O)([H])C/C=[13C]([2H])/[2H])C)OC)([H])O[C@@](O)(C(C(N(CCCC3)[C@]3([H])C(O[C@@H]2/C(C)=C/[C@H](CC[C@H]4O)C[C@H]4OC)=O)=O)=O)[C@H](C)C1

Inchi: InChI=1S/C10H10ClN/c11-9-4-5-10-8(7-9)3-1-2-6-12-10/h1,3-5,7,12H,2,6H2

Alternate CAS # 104987-11-3 for unlabelled

References: Asano, K., et al.: In Vivo, 10, 537 (1996), McCall, E., et al.: Circ. Res., 79, 1110 (1996), Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996), Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., et al.: Brit. Med. J., 318, 1104 (1999),