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Genistein
In stock
Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol
| SKU | RCLST000053 |
|---|---|
| CAS number | 446-72-0 |
| Molecular Formula | C15H10O5 |
| Catalog Number | RCLST000053 |
| Chemical Name | Genistein |
| Synonyms | 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; Baichanin A; Bonistein; 4',5,7-Trihydroxyisoflavone; GeniVida; Genisteol; NSC 36586; Prunetol; Sophoricol; |
| Molecular Weight | 270.24 |
| Solubility | DMSO, Methanol |
| Stability | Light Sensitive |
| Appearance | Light Tan to Light Yellow Solid |
| Storage Condition | Amber Vial, -20°C Freezer, Under inert atmosphere |
