rac 2-Azabicyclo[2.2.1]hept-5-en-3-one

In stock
Note:
All Products are stable to be shipped at room temperature, unless otherwise specified.
Synonyms :(+/-)-2-Azabicyclo[2.2.1]hept-5-en-3-one; (+/-)-Vince Lactam; Vince Lactam; Abacavir - In House Impurity; Abacavir Impurities

rac 2-Azabicyclo[2.2.1]hept-5-en-3-one (Abacavir - In House Impurity) is a useful reagent in the synthesis of carbocyclic sugar amines, carbanucleosides, and carbocyclic dinucleotide analogues (1). rac 2-Azabicyclo[2.2.1]hept-5-en-3-one is also an intermediate of Abacavir (A104990), a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

More Information
SKU RCL-TR-A795200
CAS number 49805-30-3
Molecular Formula C6H7NO
Catalog Number RCL-TR-A795200
Chemical Name rac 2-Azabicyclo[2.2.1]hept-5-en-3-one
Synonyms (+/-)-2-Azabicyclo[2.2.1]hept-5-en-3-one; (+/-)-Vince Lactam; Vince Lactam; Abacavir - In House Impurity; Abacavir Impurities
Boiling Pt No Data Available
Molecular Weight 109.13
Melting Pt 55-57°C
Storage Condition Refrigerator
Stability No Data Available
Appearance No Data Available
Solubility No Data Available
HS Commidity Code 2933.79.8500