Request a Quote

request4quote-icon My Quote 0
Menu
Menu
Account
main product photo

ZM 447439

In stock
Note:
All Products are stable to be shipped at room temperature, unless otherwise specified.
Synonyms :N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide;

It is a potent and selective inhibitor of Aurora B kinase. Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail. It induces apoptosos in Hep2 cancer cells and in acute myeloid leukemia cell lines but its propensity to induce polyploidy does not inevitably result in apoptosis.

More Information
SKU RCLST000784
CAS number 331771-20-1
Molecular Formula C29H31N5O4
Catalog Number RCLST000784
Chemical Name ZM 447439
Synonyms N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide;
Molecular Weight 513.59
Solubility DMSO, Methanol
Stability No Data Available
Appearance Pale Yellow Solid
Storage Condition Refrigerator

Categories

All CategoriesClose