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3-Methyl-3-(phenylmethoxy)butanamide is an intermediate used in the synthesis of (S)-N-[1-(3-Hydroxy-3-methylbutanamido)-1-oxo-3-phenylpropan-2yl]pyrazine-2-carboxamide (H805105), which is an impurity of bortezomib (B675700), which is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.

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CAS number 121490-17-3
Molecular Formula C12H17NO2
Catalog Number RCLST853622
Chemical Name 3-Methyl-3-(phenylmethoxy)butanamide
Boiling Pt No Data Available
Molecular Weight 207.27
Melting Pt No Data Available
Storage Condition -20°C Freezer
Stability No Data Available
Appearance Pale Yellow Liquid
Solubility Dichloromethane; Methanol